Immunomodulatory effect of Celecoxib on HMGB1/TLR4 pathway in a recurrent seizures model in immature rats

The post-treatment effect of CCX administration in a KA-induced seizures immature rats model was assessed in 14 PND and 30 PND animals, through clinical manifestations and expression of the pro-inflammatory molecules TLR4, HMGB1 and COX-2 in susceptible brain areas of seizures generation, and at risk of generating epileptogenesis in adulthood.83