کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8350018 | 1541821 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mutually augmenting interactions of dextromethorphan and sazetidine-A for reducing nicotine self-administration in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
A variety of nicotinic drug treatments have been found to decrease nicotine self-administration. However, interactions of drugs affecting different nicotinic receptor subtypes have not been much investigated. This study investigated the interactions between dextromethorphan, which blocks nicotinic α3β2 receptors as well as a variety of other receptors with sazetidine-A which is a potent and selective α4β2 nicotinic receptor partial agonist with desensitizing properties. This interaction was compared with dextromethorphan combination treatment with mecamylamine, which is a nonspecific nicotinic channel blocker. Co-administration of dextromethorphan (either 0.5 or 5â¯mg/kg) and lower dose of sazetidine-A (0.3â¯mg/kg) caused a significant reduction in nicotine SA. With regard to food-motivated responding, 3â¯mg/kg of sazetidine-A given alone caused a significant decrease in food intake. However, the lower 0.3â¯mg/kg sazetidine-A dose did not significantly affect food-motivated responding even when given in combination with the higher 5â¯mg/kg dextromethorphan dose which itself caused a significant decrease in food motivated responding. Interestingly, this higher dextromethorphan dose significantly attenuated the decrease in food motivated responding caused by 3â¯mg/kg of sazetidine-A. Locomotor activity was increased by the lower 0.3â¯mg/kg sazetidine-A dose and decreased by the 5â¯mg/kg dextromethorphan dose. Mecamylamine at the doses (0.1 and 1â¯mg/kg) did not affect nicotine SA, but at 1â¯mg/kg significantly decreased food-motivated responding. None of the mecamylamine doses augmented the effect of dextromethorphan in reducing nicotine self-administration. These studies showed that the combination of dextromethorphan and sazetidine-A had mutually potentiating effects, which could provide a better efficacy for promoting smoking cessation, however the strength of the interactions was fairly modest.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 166, March 2018, Pages 42-47
Journal: Pharmacology Biochemistry and Behavior - Volume 166, March 2018, Pages 42-47
نویسندگان
Edward D. Levin, Corrine Wells, Susan Slade, Amir H. Rezvani,