Neural underpinnings of maladaptive decision-making in addictions

- Individuals with addictive disorders engage in maladaptive decision-making.
- Suboptimal choices can reflect impairment in subjective evaluation of rewards.
- Various factors (delay, uncertainty, emotion, cues, peers) affect valuation.
- Valuation relies on a distributed network of brain regions.
- These regions show impaired function in addicts during decision-making.