کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8350468 1541849 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Validation and scopolamine-reversal of latent learning in the water maze utilizing a revised direct platform placement procedure
ترجمه فارسی عنوان
اعتبارسنجی و اسکوپولامین-معکوس کردن یادگیری غیرواقعی در ماز آب با استفاده از یک روش تجدید نظر مستقیم پلت فرم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Muscarinic cholinergic mechanisms, which are inactivated by scopolamine, are essential to memory for standard learning paradigms in the water maze. This experiment determined whether this would also be true for latent learning. ANOVA revealed significant negative effects of scopolamine on both speed and accuracy of trajectory, as well as significant positive effects of direct placement training vs. sham-training. In a probe trial, placement-trained animals without scopolamine spent significantly more time and path length in the target quadrant than trained rats with scopolamine and sham-trained rats without scopolamine. Scopolamine impairments are likely due to effects on memory, since the same dose had little effect on performance with a visible platform. The revised direct placement model offers a means of further comparing the neural mechanisms of latent learning with those of standard instrumental learning.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 135, August 2015, Pages 90-96
نویسندگان
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