کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8350601 | 1541850 | 2015 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chloroquine-induced scratching is mediated by NO/cGMP pathway in mice
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کلمات کلیدی
cGMPNOSnNOS7-NI7-nitroindazole - 7-نیتریدازولcyclic GMP - GMP دوره ایl-NAME - L-NAMEneuronal NOS - NOS عصبیAminoguanidine - آمینوگوئیدینscratching - خارشMice - موشcyclic guanosine monophosphate - مونوفسفات گوانوزین چرخه ایNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازChloroquine - کلروکین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Scratching behaviors were recorded by a camera after intradermal (ID) injection of CQ in the shaved rostral back of the mice. The results obtained show that CQ elicited scratching in a dose-dependent manner with a peak effective dose of 400 μg/site. Injection of non-specific NOS inhibitor, N-nitro-l-arginine methyl ester or neuronal NOS selective inhibitor and 7-nitroindazole, reduced CQ-induced scratching significantly. On the other hand, administration of aminoguanidine as inducible NOS inhibitor has no inhibitory effect on this behavior. Also, injection of l-arginine as a precursor of NO significantly increased this response. Conversely, accumulation of cGMP by sildenafil as a selective phosphodiesterase type 5 inhibitor, potentiated the scratching behavior by CQ. This study therefore shows that CQ-induced scratching behavior is mediated by the NO/cGMP pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 134, July 2015, Pages 79-84
Journal: Pharmacology Biochemistry and Behavior - Volume 134, July 2015, Pages 79-84
نویسندگان
Arash Foroutan, Nazgol Sadat Haddadi, Sattar Ostadhadi, Narges Sistany, Ahmad Reza Dehpour,