کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8350824 | 1541855 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Post-trial induction of conditioned apomorphine stimulant and inhibitory response effects: Evidence for potent trace conditioning of drug effects
ترجمه فارسی عنوان
القای تحریک متابولیسم آپومرفین و اثرات واکنش مهارکننده پس از محاکمه: شواهد برای تنظیم اثرات قوی اثرات دارویی
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کلمات کلیدی
تهویه مطبوع پاولوویان، آپومورفین، محیط زیست، دوپامین، حرکت اعتیاد،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The Pavlovian conditioning of drug effects has frequently been demonstrated using protocols that are variants of Pavlovian delay conditioning. We undertook to determine if drug conditioning could be induced using a Pavlovian trace conditioning procedure. Rats were tested in a novel open-field environment for 5Â min and in post-trial phase were injected either with vehicle, 2.0Â mg/kg or 0.05Â mg/kg apomorphine immediately or after a delay of 15Â min. The procedure was repeated three times and subsequently a 30Â min non-drug test was given. The vehicle and 15Â min post-trial apomorphine groups did not differ and in the 30Â min test their locomotion scores were equivalent to another vehicle group tested for the first time. The group that received 2.0Â mg/kg apomorphine immediately post-trial had a progressive increase in activity over the three sessions and also initially in the 30Â min test. The results for the 0.05Â mg/kg immediate post-test group were a mirror image of the 2.0Â mg/kg apomorphine group. Post-trial apomorphine treatments can induce potent conditioned effects indicative of the efficacy of trace conditioning of drug effects. These finding suggest that trace conditioning may be an important contributor to the potency of conditioned-drug effects in the development of drug addiction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 129, February 2015, Pages 79-86
Journal: Pharmacology Biochemistry and Behavior - Volume 129, February 2015, Pages 79-86
نویسندگان
Breno Garone Santos, Robert J. Carey, Marinete Pinheiro Carrera,