کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8351534 | 1541869 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antidepressant-like effect of resveratrol: Involvement of antioxidant effect and peripheral regulation on HPA axis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study focused on exploring the antidepressant potential of resveratrol (RES) and its possible mechanisms of action. Cell injury was induced by corticosterone (CORT) and detected through cell viability and contents of lactate dehydrogenase (LDH) and malonaldehyde (MDA). A rat model of depression was established through 3 weeks of consecutive chronic unpredictable mild stress (CUMS), and both the depression-like behaviors and the activity of the hypothalamic-pituitary-adrenal (HPA) axis were tested. Apart from the inhibitory effect on MDA production in vitro and in vivo, the results showed that RES (10â 10 mol/L to 10â 5 mol/L) could significantly increase the cell viability and decrease the LDH activity and that RES (15 mg/kg) treatment could alleviate the depression-like behavior of CUMS rats, as indicated by increased sucrose preference and decreased immobility in forced swimming test and tail suspension test. Rats that received RES treatment displayed a reduction of serum CORT, suggesting that RES affected the hyperactivity of the HPA axis in CUMS rats. However, RES did not affect the expression of corticotropin-releasing hormone (CRH) mRNA in the hypothalamus of CUMS rats. In summary, our results demonstrated that in addition to its widely known antioxidant properties, RES also has antidepressant-like effects, and suggested that the underlying mechanism might involve its peripheral effect on the regulation of the HPA axis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volumes 114â115, December 2013, Pages 64-69
Journal: Pharmacology Biochemistry and Behavior - Volumes 114â115, December 2013, Pages 64-69
نویسندگان
Jin-Fang Ge, Lei Peng, Jiang-Qun Cheng, Chun-Xiao Pan, Jie Tang, Fei-Hu Chen, Jun Li,