Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor

► Safinamide is an MAO B inhibitor with additional non-dopaminergic actions. ► Safinamide was tested for anti-tremor effects in the tremulous jaw movement model. ► Safinamide blocked tremor induced by cholinomimetics and dopamine antagonism. ► Safinamide may be useful for treating tremors in parkinsonism and other disorders.