Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice

► Senescence-accelerated mouse prone 8 (SAMP8), an animal model of Alzheimer's disease ► SAMP8 showed learning and memory deficit, inflammation and oxidative stress. ► Forsythiaside has improved cognitive impairments in aged SAMP8 mice. ► Forsythiaside has decreased inflammatory cytokines (interleukins 1 and 6) in brain. ► Forsythiaside has suppressed oxidative stress in brain.