Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy

► Blocking the TRPA1 channel failed to produce place reference in peripheral neuropathy. ► Blocking TRPA1 attenuated mechanical hypersensitivity in peripheral neuropathy. ► Ongoing neuropathic pain is less sensitive to blocking TRPA1 than hypersensitivity.