Glutathione peroxidases as redox sensor proteins in plant cells

Glutathione peroxidases are thiol-based enzymes that catalyze the reduction of H2O2 and hydroperoxides to H2O or alcohols, they mitigate the toxicity of these compounds to the cell mainly using thioredoxin as an electron donor. Additionally, certain redox sensor and signaling functions are being ascribed to these enzymes in prokaryotes, fungi, and plants. We review the evolutionary history, enzymatic and biochemical evidence that make GPX proteins, in addition to being peroxiredoxins, important candidates for acting as redox sensor proteins in plants: (i) the lower peroxidase activity of Cys-GPX; (ii) the thiol catalytic center; (iii) the capacity to interact with regulatory proteins. All these characteristics suggest that at the basal level, plant GPXs have an important role in redox signal transduction in addition to their peroxidase activity.