کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8361020 1542399 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Postpartum reversibility of impaired incretin effect in gestational diabetes mellitus
ترجمه فارسی عنوان
برگشت پذیری پس از زایمان از اثر تزریق در دیابت بارداری
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
The potential reversibility of a reduced incretin effect is unclear. We investigated the incretin effect during third trimester and 3 to 4 months postpartum in women with and without gestational diabetes mellitus (GDM). Ten women with GDM (plasma glucose (PG) concentration at 120 min after 75 g-oral glucose tolerance test (OGTT) (PG120min): 10.1 ± 0.6 mmol/l (mean ± SEM)) and eight women with normal glucose tolerance (NGT; PG120min: 7.0 ± 0.1 mmol/l) were investigated on four occasions: 4 h 50 g-OGTT and isoglycaemic intravenous glucose infusion during third trimester and 3 to 4 months postpartum. In women with GDM, the incretin effect increased significantly postpartum (31 ± 6 vs. 56 ± 6%, p = 0.02), whereas the increment in women with NGT was insignificant (35 ± 12 vs. 56 ± 9%, p = 0.08). Similarly, the gastrointestinal-mediated glucose disposal (GIGD = 100% × (glucoseOGTT − glucoseIIGI)/glucoseOGTT) was reduced to diabetic levels in women with GDM (37 ± 3%), but increased (p = 0.030) to normal levels post partum (58 ± 6%). GIGD did not change significantly in NGT women (48 ± 3 vs. 57 ± 6%, p = 0.94). Women with GDM exhibit a reduced incretin effect which is fully reversible alongside the restoration of normal glucose homeostasis, whereas the reduction in incretin effect during pregnancy in women with NGT was insignificant. Our results suggest that decreased incretin effect in women with GDM is a fully reversible phenomenon.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 186, 10 September 2013, Pages 104-107
نویسندگان
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