In vivo effect of glucose-dependent insulinotropic peptide (GIP) on the gene expression of calcitonin peptides in human subcutaneous adipose tissue

► We analyzed GIP effect on the CGRP-I and CT expression in subcutaneous adipose tissue. ► GIP effect was studied in clamp experiments in male obese humans. ► Very low CT expression was found in only 8 out of 116 analyzed samples. ► No influence of GIP, glucose and insulin on the CGRP-I and CT expression was observed. ► CGRP-I expression was not correlated with plasma GIP level.