[d-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, augments the effects of orally delivered exenatide and pramlintide acetate on energy balance and glycemic control in insulin-resistant male C57BLK/6-m db/db mice

► Oral delivery of exenatide and pramlintide acetate in Intravail® is feasible. ► Oral exenatide and pramlintide in Intravail® is biologically active. ► [d-Leu-4]-OB3 enhances the effects of exenatide and pramlintide acetate.