Receptor-mediated inhibition of small bowel migrating complex by GLP-1 analog ROSE-010 delivered via pulmonary and systemic routes in the conscious rat

► The GLP-1 peptide analog ROSE-010 delivered by the pulmonary route with Technosphere® inhalation powder inhibits gut motility. ► Inhibition of gut motility by ROSE-010 works through the GLP-1 receptor similar to natural GLP-1. ► Technosphere® inhalation powder has the potential of pharmaceutical use of peptides like GLP-1 and ROSE-010.