Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells

► Angiotensin II induced senescence of vascular smooth muscle cells. ► The angiotensin II-induced senescence was blocked by losartan, an AT1R antagonist. ► The angiotensin II-induced senescence was blocked by resveratrol. ► Resveratrol also inhibited angiotensin II-induced expression of p53 and p21.