Pioglitazone attenuates the detrimental effects of Advanced Glycation End-Products in the pancreatic beta cell line HIT-T15

► Pioglitazone prevents AGEs-induced cell death. ► Pioglitazone prevents AGEs-induced oxidative stress. ► Pioglitazone ameliorated AGEs-induced cell dysfunction. ► Pioglitazone attenuates intracellular RAGE signalling. ► Pioglitazone counteracts AGEs-induced pancreatic cell death and dysfunction.