Angiotensin II-induced JNK activation is mediated by NAD(P)H oxidase in isolated rat pancreatic islets

► Angiotensin II (AII) mediates signaling pathways in the pancreas of human and rat. ► AII activates JAK2/STAT1,3 and MAPKs proteins such as JNK, ERK1/2 and p38MAPK. ► JNK protein phosphorylation is mediated by NAD(P)H oxidase enzyme.