Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis

► PTHrP levels elevated in pancreas of mice treated with cerulein or ethanol. ► Sensitization by ethanol of effects of cerulein on PTHrP levels in acinar and stellate cells. ► PTHrP increases IL-6 and ICAM-1 levels in acinar cells. ► PTHrP increases procollagen I and fibronectin levels in stellate cells. ► PTHrP as mediator of inflammatory and fibrogenic response in pancreatitis.