GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress

► Endoplasmic Reticulum (ER) stress is induced by high glucose in human umbilical vein endothelial cells (HUVECs). ► GLP-1 analogue liraglutide prevented the onset of ER stress in HUVECs exposed to high glucose. ► Liraglutide may exert its effects by inducing mitochondrial fusion via OPA1 activation.