Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake

► Putative GTPase-activating protein IQGAP2 has a novel role in fatty acid metabolism. ► Iqgap2-deficient mice are protected against diet-induced fatty liver. ► Iqgap2−/− hepatocytes display a loss of the facilitated phase of fatty acid uptake.