Pharmacokinetics, tissue distribution, excretion, and antiviral activity of pegylated recombinant human consensus interferon-α variant in monkeys, rats and guinea pigs

► A new radioimmunoassay method was applied to this pharmacokinetic study. ► PEG-IFN-SA is distributed to most tissues, and excreted mainly by urine. ► A dose-dependent antiviral activity of PEG-IFN-SA in monkey serum lasts for one week. ► The Pegylated has longer half-life and antiviral action duration than the unmodified.