Prolonged effects of intracerebroventricular angiotensin II on drinking, eating and locomotor behavior in mice

► Intracranial Ang II in mice causes an acute dipsogenic effect via the AT1 receptor. ► The effect is followed by sustained profound antidipsogenic effect. ► Central Ang II also suppresses voluntary locomotion and food consumption. ► Such inhibitory effects persist throughout the entire dark phase of diurnal cycle. ► The effects imply a role for central Ang II in regulating metabolic homeostasis.