Leptin-programmed rats respond to cold exposure changing hypothalamic leptin receptor and thyroid function differently from cold-exposed controls

► Neonatal hyperleptinemia programs for higher body weight, food intake and lower hypothalamic OBR. ► Cold exposure restores most of altered parameters induced by neonatal hyperleptinemia. ► Cold exposure further increases the higher T4 and decreases the brown adipose type 2 deiodinase. ► Cold affects the central leptin receptor and thyroid function in adult animals programmed by postnatal hyperleptinemia.