GLP-1-derived nonapeptide GLP-1(28-36)amide inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese mice

► GLP-1(28-36)amide, derived from GLP-1, has insulin-like actions in obese mice. ► The nonapeptide inhibits weight gain and the development of insulin resistance. ► It also attenuates diabetes and hepatic steatosis. ► No effects of GLP-1(28-36)amide are seen in normal lean, insulin-sensitive mice. ► GLP-1(28-36)amide might be a treatment for metabolic syndrome.