Leptin differentially regulates NPY secretion in hypothalamic cell lines through distinct intracellular signal transduction pathways

►NPY secretion is regulated by leptin in two clonal hypothalamic cells lines. ►NPY is differentially regulated by activation of specific signaling pathways. ►Leptin activates AMPK to up-regulate NPY secretion. ►Leptin acts through MAPK and PI3K to suppress NPY secretion.