Cell cycle regulation and proliferation in lichen sclerosus

► Genital lichen sclerosus is considered a percursor lesion of squamous cell carcinoma. ► p53 is significantly overexpressed in genital lichen sclerosus. ► Proliferation markers (MCM3, Ki-67) are overexpressed in genital lichen sclerosus. ► Cell cycle regulation and proliferation is different in extragenital lichen sclerosus.