Oral delivery of octreotide acetate in Intravail® improves uptake, half-life, and bioavailability over subcutaneous administration in male Swiss Webster mice

► Oral delivery of octreotide acetate in Intravail® is feasible. ► Oral delivery of octreotide acetate in Intravail® increases serum uptake. ► Oral delivery of octreotide acetate in Intravail® improves serum half-life. ► Oral delivery of octreotide acetate in Intravail® increases bioavailability. ► Oral delivery of octreotide acetate in Intravail® is noninvasive and safe.