کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8361738 1542519 2018 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Foxo transcription factors in T cell biology and tumor immunity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Foxo transcription factors in T cell biology and tumor immunity
چکیده انگلیسی
The evolutionally conserved forkhead box O (Foxo) family of transcription factors is pivotal in the control of nutrient sensing and stress responses. Recent studies have revealed that the Foxo proteins have been rewired to regulate highly specialized T cell activities. Here, we review the latest advances in the understanding of how Foxo transcription factors control T cell biology, including T cell trafficking, naive T cell homeostasis, effector and memory responses, as well as the differentiation and function of regulatory T cells. We also discuss the emerging evidence on Foxo-mediated regulation in antitumor immunity. Future work will further explore how the Foxo-dependent programs in T cells can be exploited for cancer immunotherapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 50, June 2018, Pages 13-20
نویسندگان
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