کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8362170 1542532 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alpha2beta1 integrin in cancer development and chemoresistance
ترجمه فارسی عنوان
آلفا 2 بتا 1 انتگرال در توسعه سرطان و کمبود مقاومت
کلمات کلیدی
آلفا 2 بتا 1 انتگرال، کلاژن، متاستاز، مقاومت شیمیایی، بدخیم های هماتولوژیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Extracellular matrix, via its receptors the integrins, has emerged as a crucial factor in cancer development. The α2β1 integrin is a major collagen receptor that is widely expressed and known to promote cell migration and control tissue homeostasis. Growing evidence suggests that it can be a key pathway in cancer. Recent studies have shown that α2β1 integrin is a regulator of cancer metastasis either by promoting or inhibiting the dissemination process of cancer cells. The α2β1 integrin signaling can also enhance tumor angiogenesis. Emerging evidence supports a role for α2β1 integrin in cancer chemoresistance especially in hematological malignancies originating from the T cell lineage. In addition, α2β1 integrin has been associated with cancer stem cells. In this review, we will discuss the complex role of α2β1 integrin in these processes. Collagen is a major matrix protein of the tumor microenvironment and thus, understanding how α2β1 integrin regulates cancer pathogenesis is likely to lead to new therapeutic approaches and agents for cancer treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 35, December 2015, Pages 145-153
نویسندگان
, , ,