کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
837540 | 908342 | 2012 | 28 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The triplex vaccine effects in mammary carcinoma: A nonlinear model in tune with SimTriplex The triplex vaccine effects in mammary carcinoma: A nonlinear model in tune with SimTriplex](/preview/png/837540.png)
This paper deals with the mathematical modeling of the mammary carcinoma–immune system competition elicited by an external stimulus represented by three different protocols of the triplex vaccine [C. De Giovanni, et al., Immunoprevention of HER-2/neu transgenic mammary carcinoma through an interleukin 12-engineered allogeneic cell vaccine, Cancer Research 64 (2004) 4001–4009]. The presented model is composed of nonlinear ordinary differential equations based on parameters and cell populations. A qualitative analysis of the asymptotic behavior of the model and numerical simulations are able to depict preclinical experiments on transgenic mice in tune with the SimTriplex model [F. Pappalardo, F. Castiglione, P.L. Lollini, S. Motta, Modelling and simulation of cancer immunoprevention vaccine, Bioinformatics 21 (2005) 2891–2897]. The results are of great interest both in the applied and theoretical sciences.
Journal: Nonlinear Analysis: Real World Applications - Volume 13, Issue 4, August 2012, Pages 1913–1940