Association of BRCA2 variants with breast cancer risk: A meta-analysis

BRCA2 is a tumor suppressor gene involved in repair of double strand breaks in DNA. Germ line mutations within this gene are implicated in familial breast and ovary cancer syndromes. Moreover, several studies have assessed association between single nucleotide polymorphisms (SNPs) within this gene and risk of breast cancer. We performed a meta-analysis to assess the association between rs4987117, rs1799955, rs766173, rs15869 SNPs within BRCA2 gene and risk of breast cancer. The pooled odds ratios (ORs) and its 95% confidence intervals (CIs) were calculated using fixed and random model to define the association between these polymorphisms and breast cancer risk. The rs1799955 has been significantly associated with an increased risk of breast cancer in allelic, homozygous and dominant models. Other SNPs were not associated with breast cancer risk in any of assessed genetic models. The present meta-analysis provides evidences for association of rs1799955 and breast cancer.