کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8401148 | 1544479 | 2015 | 51 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Branching and oscillations in the epigenetic landscape of cell-fate determination
ترجمه فارسی عنوان
شاخه ها و نوسانات در چشم انداز اپی ژنتیکی سلول تعیین سرنوشت
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کلمات کلیدی
شبکه نظارتی ژنی، سلول های بنیادی، نیروی انسانی، زیست شناسی مصنوعی، چندتایی بودن، جاذبه،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
چکیده انگلیسی
The well-known Waddington's epigenetic landscape of cell-fate determination is not static but varies because of the dynamic gene regulation during development. However, existing mathematical models with few state variables and fixed parameters are inadequate in characterizing the temporal transformation of the landscape. Here we simulate a decision-switch model of gene regulation with more than two state variables and with time-varying repression among regulatory factors. We are able to demonstrate multi-lineage differentiation at different timescales that portrays the branching canals in Waddington's illustration. We also present a repressilator-type system that activates suppressed genes via sustained oscillations in a flattened landscape, hence providing an alternative scheme for cellular reprogramming. The time-dependent parameters governed by gradient-based dynamics regulate cell differentiation, dedifferentiation and transdifferentiation. Our prediction integrates the theories of branching and structural oscillations in cell-fate determination, which reveals key temporal patterns of cell differentiation and associated diseases, such as cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Biophysics and Molecular Biology - Volume 117, Issues 2â3, March 2015, Pages 240-249
Journal: Progress in Biophysics and Molecular Biology - Volume 117, Issues 2â3, March 2015, Pages 240-249
نویسندگان
Jomar Fajardo Rabajante, Ariel Lagdameo Babierra,