کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8406586 1544944 2018 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence for the implication of the histone code in building the genome structure
ترجمه فارسی عنوان
شواهد برای اثبات کد هیستون در ساخت ساختار ژنوم
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات مدل‌سازی و شبیه سازی
چکیده انگلیسی
Histones are punctuated with small chemical modifications that alter their interaction with DNA. One attractive hypothesis stipulates that certain combinations of these histone modifications may function, alone or together, as a part of a predictive histone code to provide ground rules for chromatin folding. We consider four features that relate histone modifications to chromatin folding: charge neutralisation, molecular specificity, robustness and evolvability. Next, we present evidence for the association among different histone modifications at various levels of chromatin organisation and show how these relationships relate to function such as transcription, replication and cell division. Finally, we propose a model where the histone code can set critical checkpoints for chromatin to fold reversibly between different orders of the organisation in response to a biological stimulus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 164, February 2018, Pages 49-59
نویسندگان
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