کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8407006 | 1544969 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
On learning time delays between the spikes from different input neurons in a biophysical model of a pyramidal neuron
ترجمه فارسی عنوان
در یادگیری تاخیر زمانی بین سنبله ها از نورون های ورودی مختلف در یک مدل بیوفیزیکی یک نورون هرم
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کلمات کلیدی
تاخیر انتشار دندریتیک، تشخیص همزمان، سر و صدا غشاء، مقیاس سیناپتیس،
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
مدلسازی و شبیه سازی
چکیده انگلیسی
Biological systems are able to recognise temporal sequences of stimuli or compute in the temporal domain. In this paper we are exploring whether a biophysical model of a pyramidal neuron can detect and learn systematic time delays between the spikes from different input neurons. In particular, we investigate whether it is possible to reinforce pairs of synapses separated by a dendritic propagation time delay corresponding to the arrival time difference of two spikes from two different input neurons. We examine two subthreshold learning approaches where the first relies on the backpropagation of EPSPs (excitatory postsynaptic potentials) and the second on the backpropagation of a somatic action potential, whose production is supported by a learning-enabling background current. The first approach does not provide a learning signal that sufficiently differentiates between synapses at different locations, while in the second approach, somatic spikes do not provide a reliable signal distinguishing arrival time differences of the order of the dendritic propagation time. It appears that the firing of pyramidal neurons shows little sensitivity to heterosynaptic spike arrival time differences of several milliseconds. This neuron is therefore unlikely to be able to learn to detect such differences.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 136, October 2015, Pages 80-89
Journal: Biosystems - Volume 136, October 2015, Pages 80-89
نویسندگان
Achilleas Koutsou, Guido Bugmann, Chris Christodoulou,