کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8408500 1545070 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibody H3 Structure Prediction
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Antibody H3 Structure Prediction
چکیده انگلیسی
Antibodies are proteins of the immune system that are able to bind to a huge variety of different substances, making them attractive candidates for therapeutic applications. Antibody structures have the potential to be useful during drug development, allowing the implementation of rational design procedures. The most challenging part of the antibody structure to experimentally determine or model is the H3 loop, which in addition is often the most important region in an antibody's binding site. This review summarises the approaches used so far in the pursuit of accurate computational H3 structure prediction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational and Structural Biotechnology Journal - Volume 15, 2017, Pages 222-231
نویسندگان
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