کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8413033 | 1545327 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mucus permeating carriers: formulation and characterization of highly densely charged nanoparticles
ترجمه فارسی عنوان
حامل های نفوذی مخاط: فرمولاسیون و خصوصی سازی نانوذرات با گرانروی بسیار بالا
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کلمات کلیدی
ذرات نفوذی مخاطی، نفوذ، موکوس، هیدروفلوئید کیتوزان، کندرویتین سولفات،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
چکیده انگلیسی
The GI mucus layer represents a significant block to drug carriers absorption. Taking an example from nature, virus-mimicking nanoparticles (NPs) with highly densely charged surface were designed with the aim to improve their mucus permeation ability. NPs were formulated by combining chitosan with chondroitin sulfate and were characterized by particle size, ζ-potential and hydrophobicity. The interaction occurring between NPs and diluted porcine intestinal mucus was investigated by a new method. Furthermore, the rotating tube technique was exploited to evaluate the NPs permeation ability in fresh undiluted porcine intestinal mucus. NPs (400-500 nm) presenting a slightly positive (4.02 mV) and slightly negative (â3.55 mV) ζ-potential resulted to be hydrophobic and hydrophilic, respectively. On the one hand the hydrophobic NPs undergo physico-chemical changes when incubated with mucus, namely the size increased and the ζ-potential decreased. On the other hand, the hydrophilic NPs did not significantly change size and net charge during incubation with mucus. Both types of NPs showed a 3-fold higher diffusion ability compared to the reference 50/50 dl-lactide/glycolide copolymer NPs (136 nm, â23 mV, hydrophilic). Based on these results, this work gives valuable information for the further design of mucus-penetrating NPs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 97, Part A, November 2015, Pages 273-279
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 97, Part A, November 2015, Pages 273-279
نویسندگان
Irene Pereira de Sousa, Corinna Steiner, Matthias Schmutzler, Matthew D. Wilcox, Gert J. Veldhuis, Jeffrey P. Pearson, Christian W. Huck, Willi Salvenmoser, Andreas Bernkop-Schnürch,