کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8414104 | 1545343 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis
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کلمات کلیدی
burning sensationBacking layerFISPLSNaCMCFDMFRTApISPEFPCA - PCAEthylcellulose - اتیل سلولزPain sensation - احساس دردIn vivo evaluation - ارزیابی in vivoPolyethylene oxide - اکسید پلی اتیلنMultivariate data analysis - تجزیه و تحلیل داده های چند متغیرهPrincipal component analysis - تحلیل مولفههای اصلی یا PCAIn vitro testing - تست آزمایشگاهیPartial least square regression - حداقل رگرسیون حداقل مربعItching - خارشspontaneous - خود جوشCFD - دینامیک سیالاتResidence time - زمان اقامتActive pharmaceutical ingredients - مواد تشکیل دهنده دارویی فعالPAS - نهPEO - پیوGly - گلیGlycerol - گلیسرول یا گلیسیرین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Mucoadhesive films represent the most developed medical form of buccal application. Despite the intense focus on buccal film-based systems, there are no standardized methods for their evaluation, which limits the possibility of comparison of obtained data and evaluation of the significance of influence of formulation and process variables on properties of resulting films. The used principal component analysis, together with a partial least squares regression provided a unique insight into the effects of in vitro parameters of mucoadhesive buccal films on their in vivo properties and into interdependencies among the studied variables. In the present study eight various mucoadhesive buccal films based on mucoadhesive polymers (carmellose, polyethylene oxide) were prepared using a solvent casting method or a method of impregnation, respectively. An ethylcellulose or hydrophobic blend of white beeswax and white petrolatum were used as a backing layer. The addition of polyethylene oxide prolonged the in vivo film residence time (from 53.24 ± 5.38-74.18 ± 5.13 min to 71.05 ± 3.15-98.12 ± 1.75 min), and even more when combined with an ethylcellulose backing layer (98.12 ± 1.75 min) and also improved the film's appearance. Tested non-woven textile shortened the in vivo film residence time (from 74.18 ± 5.13-98.12 ± 1.75 min to 53.24 ± 5.38-81.00 ± 8.47 min) and generally worsened the film's appearance. Mucoadhesive buccal films with a hydrophobic backing layer were associated with increased frequency of adverse effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 86, Issue 3, April 2014, Pages 498-506
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 86, Issue 3, April 2014, Pages 498-506
نویسندگان
David Vetchý, Hana Landová, Jan Gajdziok, Petr Doležel, ZdenÄk DanÄk, Jan Å tembÃrek,