کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8414426 | 1545346 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessment of absorption potential of poorly water-soluble drugs by using the dissolution/permeation system
ترجمه فارسی عنوان
ارزیابی پتانسیل جذب داروهای محلول در آب با استفاده از سیستم انحلال / نفوذ
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کلمات کلیدی
انحلال، حداکثر دوز قابل جذب داروی محلول در آب بسیار ضعیف است گام محدود کننده سرعت، انحلال پذیری،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
چکیده انگلیسی
This study aims to assess the absorption potential of oral absorption of poorly water-soluble drugs by using the dissolution/permeation system (D/P system). The D/P system can be used to perform analysis of drug permeation under dissolution process and can predict the fraction of absorbed dose in humans. When celecoxib at 1/100 of a clinical dose was applied to the D/P system, percentage of dose dissolved and permeated significantly decreased with an increase in the applied amount, resulting in the oral absorption being predicted to be 22-55%. Whereas similar dissolution and permeation profiles of montelukast sodium were observed, estimated absorption (69-85%) was slightly affected. Zafirlukast absorption (33-36%) was not significantly affected by the dose, although zafirlukast did not show complete dissolution. The relationship between clinical dose and predicted oral absorption of drugs corresponded well to clinical observations. The limiting step of the oral absorption of celecoxib and montelukast sodium was solubility, while that of zafirlukast was dissolution rate. However, due to high permeability of montelukast, oral absorption was not affected by dose. Therefore, the D/P system is a useful tool to assess the absorption potential of poorly water-soluble drugs for oral use.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 85, Issue 3, Part B, November 2013, Pages 1317-1324
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 85, Issue 3, Part B, November 2013, Pages 1317-1324
نویسندگان
Makoto Kataoka, Koji Yano, Yoriko Hamatsu, Yoshie Masaoka, Shinji Sakuma, Shinji Yamashita,