Biodistribution of Nanostructured Lipid Carriers (NLCs) after intravenous administration to rats: Influence of technological factors

Nanostructured Lipid Carriers (NLCs) differing on particle size, surface charge, and surfactant content were radiolabeled with 99mTc and intravenously administered to rats. The kinetic biodistribution profile for each formulation was analyzed, exhibiting all of them a long circulating time in blood and greater accumulation in the kidneys, bone marrow, liver, and spleen.