کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8415097 1545465 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Micronuclei Formation and 8-Hydroxy-2-Deoxyguanosine Enzyme Detection in Ovarian Tissues After Radiofrequency Exposure at 1800 MHz in Adult Sprague-Dawley Rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Micronuclei Formation and 8-Hydroxy-2-Deoxyguanosine Enzyme Detection in Ovarian Tissues After Radiofrequency Exposure at 1800 MHz in Adult Sprague-Dawley Rats
چکیده انگلیسی
Human fertility and its correlation to ovarian function and cytological changes are linked to ever-increasing use of mobile phones. Wireless communications have become a critical topic of concern because of an increasing number of studies in this field with controversial outcomes. The aim of this study was to assess the genotoxic effect of GSM frequency at 1800 MHz on ovarian function. Sixty female Sprague-Dawley rats were distributed over six groups (control group and the exposure groups with whole-body exposure for 2 h/day, 7 days/week for 15, 30 and 60 continuous days). The study investigated the oxidative stress, 8-hydroxy-2-deoxyguanosine enzyme, micronuclei formation and histopathological changes in ovarian tissue. The results showed an induced oxidative stress via an increase in lipid peroxidation and decreased antioxidant enzyme activity. There was also an elevation in the 8-hydroxy-2-deoxyguanosine enzyme and an increased rate of micronuclei formation in ovarian tissues of exposed animals with 60-day exposure compared with control animals. Cytological changes were recorded such as micronuclei formation, vacuolation, degeneration and impaired folliculogenesis. The study suggests that GSM frequency at 1800 MHz was negatively impacted on female reproductive performances mediated by oxidative stress induction and 8-hydroxy-2-deoxyguanosine formation leading to overall impaired ovarian function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: HAYATI Journal of Biosciences - Volume 24, Issue 2, April 2017, Pages 79-86
نویسندگان
, , , , , , ,