کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8428764 1546110 2017 44 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
چکیده انگلیسی
Sulforaphane, as a pure chemical, protects against chemical-induced skin, oral, stomach, colon, lung and bladder carcinogenesis and in genetic models of colon and prostate carcinogenesis. In many of these settings the antitumorigenic efficacy of sulforaphane is dampened in Nrf2-disrupted animals. Broccoli preparations rich in glucoraphanin or sulforaphane exert demonstrable pharmacodynamic action in over a score of clinical trials. Measures of NRF2 pathway response and function are serving as guideposts for the optimization of dose, schedule and formulation as clinical trials with broccoli-based preparations become more commonplace and more rigorous in design and implementation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Food Science & Technology - Volume 69, Part B, November 2017, Pages 257-269
نویسندگان
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