کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8428768 | 1546110 | 2017 | 63 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Strategies for the discovery and identification of food protein-derived biologically active peptides
ترجمه فارسی عنوان
استراتژی برای کشف و شناسایی پپتیدهای فعال بیولوژیکی پروتئین غذایی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
Targeted approaches have, in certain instances, resulted in the development of particularly potent BAPs/hydrolysates and the discovery of novel BAP sequences. In addition, significant progress has been made in the identification of short peptides, involving the utilisation of multi-stage processes combining various physicochemical, analytical and in silico tools. This has allowed identification of novel sequences which are more relevant to human health from a bioavailability and stability perspective. BAPs have successfully been detected and quantified in human samples (e.g., serum, intestinal contents and urine) using different liquid chromatography-mass spectrometric (LC-MS) methodologies. In addition, human dose-response studies have allowed determination of their in vivo potency and efficacy, which in turn contributes to the development of scientific dossiers for regulatory approval.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Food Science & Technology - Volume 69, Part B, November 2017, Pages 289-305
Journal: Trends in Food Science & Technology - Volume 69, Part B, November 2017, Pages 289-305
نویسندگان
Alice B. Nongonierma, Richard J. FitzGerald,