Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression

We conclude that most neuroblastoma cell lines are sensitive to YM155 in the low nM range and that resistant cells can be sensitised by ABCB1 inhibitors. Therefore YM155 is a promising novel compound for treatment of neuroblastoma with low ABCB1 expression.