کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8455530 1548024 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review: Molecular mechanism of microglia stimulated glioblastoma invasion
ترجمه فارسی عنوان
نقد و بررسی: مکانیزم مولکولی میکروگلاییا باعث تحریک گلیوبلاستوم می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Glioblastoma multiforme is one of the deadliest human cancers and is characterized by a high degree of microglia and macrophage infiltration. The role of these glioma infiltrating macrophages (GIMs) in disease progression has been the subject of recent investigation. While initially thought to reflect an immune response to the tumor, the balance of evidence clearly suggests GIMs can have potent tumor-tropic functions and assist in glioma cell growth and infiltration into normal brain. In this review, we focus on the evidence for GIMs aiding mediating glioblastoma motility and invasion. We survey the literature for molecular pathways that are involved in paracrine interaction between glioma cells and GIMs and assess which of these might serve as attractive targets for therapeutic intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Matrix Biology - Volume 32, Issues 7–8, October–November 2013, Pages 372-380
نویسندگان
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