کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8456025 1548363 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heavy charged particle radiobiology: Using enhanced biological effectiveness and improved beam focusing to advance cancer therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Heavy charged particle radiobiology: Using enhanced biological effectiveness and improved beam focusing to advance cancer therapy
چکیده انگلیسی
Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 711, Issues 1–2, 3 June 2011, Pages 150-157
نویسندگان
, , , ,