کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8458233 | 1548868 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression profiles of Annexin A1, formylated peptide receptors and cyclooxigenase-2 in gastroesophageal inflammations and neoplasias
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کلمات کلیدی
S.E.MDABADCCOX-2Anxa1ERKμMFPRBSA - BSA°C - ° CAdenocarcinoma - آدنوکارسینوماinflammation - التهاب( توروم) analysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceTumors - تومورهاstandard error of mean - خطای استاندارد میانگینVersus - در مقابلcyclooxygenase 2 - سیکلوکوکسیژناز 2sample number - شماره نمونهCorrelation coefficient - ضریب همبستگیmicrometer - میکرومترhematoxylin-eosin - هماتوکسیلین ائوزینextracellular signal-related kinase - کیناز مرتبط با سیگنال خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The antiâinflammatory protein AnnexinâA1 (ANXA1) is associated to tumor invasion process and its actions can be mediated by formylated peptides receptors (FPRs). Therefore, we evaluated the expression and correlation of ANXA1, FPR and cyclooxygenaseâ2 (COXâ2) enzyme in esophageal and stomach inflammations and neoplasias. The study of proteins was performed by immunohistochemistry in biopsies of esophagitis, Barrett's esophagus, squamous cell carcinoma and adenocarcinoma of the esophagus, as well as gastritis, stomach polypus and gastric adenocarcinoma. The intensity of the expressions was evaluated by densitometry. The immunohistochemical and densitometric analyzes showed specificity for the FPR1 receptor and modulation of the ANXA1, COXâ2 and FPR1 expressions in the epithelial cells in the different studied conditions. Increased immunoreactivity of these proteins was observed in cases of inflammation and stomach polypus. Interestingly, moderate immunoreactivity for ANXA1 and FPR1 but increased immunolabeling for COXâ2 were observed in BarrettÌs esophagus and esophageal adenocarcinomas. Also, there was reduced expression of ANXA1 and FPR1 in esophageal carcinoma but COXâ2 overexpression in this tumor. There was no expression of FPR2 but ANXA1 and FPR1 expressions were positively correlated in all clinical conditions studied. Positive correlation between ANXA1 and COXâ2 were also observed in inflammation conditions while negative correlation between ANXA1 and COXâ2 was observed in esophageal carcinoma. Our results demonstrate the unregulated expression of ANXA1 and COXâ2 in precursor lesions of esophageal and stomach cancers, reinforcing their involvement in gastroesophageal carcinogenesis. In addition, the data show that the actions of ANXA1 in the inflammatory and neoplastic processes of the esophagus and stomach are specifically mediated by the FPR1 receptor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 214, Issue 2, February 2018, Pages 181-186
Journal: Pathology - Research and Practice - Volume 214, Issue 2, February 2018, Pages 181-186
نویسندگان
Rodolfo T.C. Takaoka, Nathália D. Sertório, Lara P.J. Magalini, Leandro M. Dos Santos, Helena R. Souza, Melina M. Iyomasa-Pilon, Lucas Possebon, Sara S. Costa, Ana P. Girol,