کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8462594 | 1549036 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunohistochemical study on the distribution of insulin-like growth factor-binding protein 4 in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic lateral sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
In the present study, we used the SOD1G93A mutant transgenic mice as an in vivo model of amyotrophic lateral sclerosis (ALS) and performed immunohistochemical studies to investigate the changes of insulin-like growth factor-binding protein 4 (IGFBP4) in the central nervous system. Decreased expression of IGFBP4 was obvious in the cerebral cortex, hippocampus, cerebellar cortex and inferior olive of SOD1G93A transgenic mice. In the cerebral cortex, there was a significant decrease in IGFBP4 immunoreactivity in the pyramidal cells. In the hippocampal formation, IGFBP4 immunoreactivity was also decreased in the pyramidal cells of CA1-3 areas and the granule cells of dentate gyrus. In the cerebellar cortex, IGFBP4 immunoreactivity was prominent in the granular layer in wtSOD1 transgenic mice, compared to that in SOD1G93A transgenic mice. IGFBP4 immunoreactivity was decreased in the inferior olive of SOD1G93A transgenic mice. This study, showing decreased IGFBP4 in different brain regions of SOD1G93A transgenic mice, may provide clues to understanding the differential susceptibility of neural structures in ALS, suggesting a role of IGFBP4 in an abnormality of cognitive and/or motor function in ALS. The mechanisms and functional implications of these decreases require elucidation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Anatomy - Anatomischer Anzeiger - Volume 190, Issue 6, 20 December 2008, Pages 502-509
Journal: Annals of Anatomy - Anatomischer Anzeiger - Volume 190, Issue 6, 20 December 2008, Pages 502-509
نویسندگان
Dong Woo Kang, Yoon Hee Chung, Jae Chul Lee, Joon Seok Bang, Daejin Kim, Sung Su Kim, Kyung Yong Kim, Won Bok Lee, Choong Ik Cha,