Microtubule proliferation in right ventricular myocytes of rats with monocrotaline-induced pulmonary hypertension

► Myocyte microtubule cytoskeleton from pulmonary hypertensive rats was proliferated. ► Disruption of proliferated microtubules did not modify myocyte contraction. ► Microtubule proliferation is a common response to pulmonary hypertension. ► Contractile response to disruption is dependent upon the level of proliferation.