Interaction between maternal and postnatal high fat diet leads to a greater risk of myocardial dysfunction in offspring via enhanced lipotoxicity, IRS-1 serine phosphorylation and mitochondrial defects

► Maternal nutritional environment programs cardiac anomalies in offspring ► Maternal fat exposure predisposes mitochondrial injury in the offspring. ► Maternal fat exposure predisposes intracellular Ca2 + mishandling in the offspring.